Hydrophobicity scales

Several hydrophobicity scales have been published for various uses. Many of the commonly used hydrophobicity scales are described below.

Many more scales have been published throughout the last three decades. Even though more advanced methods have been developed for prediction of membrane spanning regions, the simple and very fast calculations are still highly used.

aa aa Kyte-Doolittle Hopp-Woods Cornette Eisenberg Rose Janin Engelman GES
A Alanine 1.80 -0.50 0.20 0.62 0.74 0.30 1.60
C Cysteine 2.50 -1.00 4.10 0.29 0.91 0.90 2.00
D Aspartic acid -3.50 3.00 -3.10 -0.90 0.62 -0.60 -9.20
E Glutamic acid -3.50 3.00 -1.80 -0.74 0.62 -0.70 -8.20
F Phenylalanine 2.80 -2.50 4.40 1.19 0.88 0.50 3.70
G Glycine -0.40 0.00 0.00 0.48 0.72 0.30 1.00
H Histidine -3.20 -0.50 0.50 -0.40 0.78 -0.10 -3.00
I Isoleucine 4.50 -1.80 4.80 1.38 0.88 0.70 3.10
K Lysine -3.90 3.00 -3.10 -1.50 0.52 -1.80 -8.80
L Leucine 3.80 -1.80 5.70 1.06 0.85 0.50 2.80
M Methionine 1.90 -1.30 4.20 0.64 0.85 0.40 3.40
N Asparagine -3.50 0.20 -0.50 -0.78 0.63 -0.50 -4.80
P Proline -1.60 0.00 -2.20 0.12 0.64 -0.30 -0.20
Q Glutamine -3.50 0.20 -2.80 -0.85 0.62 -0.70 -4.10
R Arginine -4.50 3.00 1.40 -2.53 0.64 -1.40 -12.3
S Serine -0.80 0.30 -0.50 -0.18 0.66 -0.10 0.60
T Threonine -0.70 -0.40 -1.90 -0.05 0.70 -0.20 1.20
V Valine 4.20 -1.50 4.70 1.08 0.86 0.60 2.60
W Tryptophan -0.90 -3.40 1.00 0.81 0.85 0.30 1.90
Y Tyrosine -1.30 -2.30 3.20 0.26 0.76 -0.40 -0.70

Other useful resources

AAindex: Amino acid index database
http://www.genome.ad.jp/dbget/aaindex.html